What it is
FOXO4-DRI at a glance
Cell-penetrating peptide designed to disrupt FOXO4-p53 interaction
Reported to clear senescent cells in mouse models; human safety/efficacy is unestablished.
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Peptide guide
FOXO4-DRI Peptide Guide & Supplier Listing Notes
Cell-penetrating peptide designed to disrupt FOXO4-p53 interaction
Reported to clear senescent cells in mouse models; human safety/efficacy is unestablished.
Educational disclaimer
Informational reference only
This page is for educational and informational purposes only. PeptideSuppliers.org does not sell peptides, provide medical advice, or recommend human use.
Research context
Where current research places it
Cellular senescence, aging biology, apoptosis of senescent cells
Preclinical mouse/cell research
Research overview
Use the linked literature searches for current papers and trial records.
Current summary
What research has looked at
Reported to clear senescent cells in mouse models; human safety/efficacy is unestablished.
Evidence stage
How mature the research is
Preclinical mouse/cell research
Source links
Open current literature searches
Mechanism
How FOXO4-DRI is designed to target senescent cells
FOXO4-DRI is a cell-penetrating, D-retro-inverso peptide engineered to disrupt the interaction between FOXO4 and p53 inside senescent ("zombie") cells. In mouse studies, disrupting that interaction triggered apoptosis specifically in senescent cells while appearing to spare healthy ones, which is the core mechanism behind its senolytic research interest.
The "DRI" in its name refers to a peptide-engineering technique that reverses the amino acid sequence and substitutes D-amino acids, making the peptide more resistant to enzymatic breakdown and better able to cross cell membranes than a standard peptide of the same sequence.
Storage and handling notes
What clear supplier pages show
This category benefits from precise storage language, clear batch references, and product pages that separate documentation from headline copy.
- Check whether the page clearly states the compound format being referenced.
- Look for storage language that matches the label and any linked laboratory documentation.
- Compare whether lot, batch, or COA references remain easy to access after the product details.
- Note whether the page explains container, seal, or light-protection details in plain language.
Choosing a supplier page
What to compare when opening listings
The clearest FOXO4-DRI listings explain the technical label, keep the category context readable, and make documentation references easier to compare.
FOXO4-DRI pages are more credible when they rely on careful wording, category clarity, and laboratory documentation instead of futuristic or outcome-based language.
Linked supplier pages
Use these pages to compare naming, documentation access, and overall page clarity.
Supplier listing
Iron Peptides
This listing is useful for checking naming, documentation access, and overall page clarity.
10% off with code IRONMANFrequently asked questions
Quick answers to the main questions that come up on this page.
What is FOXO4-DRI?
Cell-penetrating peptide designed to disrupt FOXO4-p53 interaction
What research areas is it linked to?
Cellular senescence, aging biology, apoptosis of senescent cells
Preclinical mouse/cell research
What should stand out when comparing supplier pages?
The clearest FOXO4-DRI listings explain the technical label, keep the category context readable, and make documentation references easier to compare.
What does "DRI" mean in FOXO4-DRI?
DRI stands for D-retro-inverso, a peptide-engineering technique that reverses the amino acid sequence and uses D-amino acids to resist enzymatic breakdown and improve cell penetration.
Has FOXO4-DRI been tested in humans?
No. Published evidence is currently limited to mouse and cell-culture models, and human safety and efficacy remain unestablished.